Integrin-engaged Cellular Patches Mechanically Impose a Mitochondrial Respiratory Bottleneck to Suppress Cancer Cell Motility
Qizheng Zhang, Sona Rani Roy, Tianrui Zhao, Wenjing Hou, Chenjie Xu, Jiancan Yu, Kai Wu, Xunwu Hu, Ye Zhang
This study shows that integrin-mediated mechanotransduction through supramolecular ligand clustering limits mitochondrial respiratory capacity, thereby suppressing cancer cell motility and tumor growth.
bioRxiv · Jul 8, 2026 · PreprintBiophysics