Loss of Flotillin-2 enhances trastuzumab emtansine internalization and cytotoxicity by relieving negative regulation of HER2 internalization in HER2-amplified cancers
David John Wisniewski, Rachel K Pritz, Jake Munch, Diya Desai, Tzu‐Ting Huang, Sachin K Deshmukh, Sharon K. Wu, Laurent Désaubry, George W. Sledge, Jung-Min Lee, Natalie Porat‐Shliom, Stanley Lipkowitz
This study shows that reducing Flotillin-2 increases T-DM1 internalization and cytotoxicity in HER2-amplified cancers by enhancing HER2 ubiquitination and internalization.
bioRxiv · May 19, 2026 · PreprintCancer Biology