Author

Jake Munch

National Cancer InstituteORCID 0000-0002-5527-3503Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

David John WisniewskiiD· 1 shared Diya Desai· 1 shared George W. SledgeiD· 1 shared Jung-Min Lee· 1 shared Laurent DésaubryiD· 1 shared Natalie Porat‐ShliomiD· 1 shared Rachel K Pritz· 1 shared Sachin K Deshmukh· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

David John WisniewskiORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintMay 19, 2026

Loss of Flotillin-2 enhances trastuzumab emtansine internalization and cytotoxicity by relieving negative regulation of HER2 internalization in HER2-amplified cancers

David John Wisniewski, Rachel K Pritz, Jake Munch…·Stanley Lipkowitz

This study shows that reducing Flotillin-2 increases T-DM1 internalization and cytotoxicity in HER2-amplified cancers by enhancing HER2 ubiquitination and internalization.

DOI 10.64898/2026.05.15.725439

humanproteomics

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