Paul Hoover

The paper identifies spatially distinct macrophage-fibroblast interactions in lupus nephritis that drive myofibroblast heterogeneity and fibrosis.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze myeloid cell dynamics in lupus nephritis, showing shifts in immune responses linked to disease progression.

This study identifies huTLR8's role in placental defects and pregnancy loss in lupus mice, showing its involvement in immune dysregulation and inflammation.

The paper identifies three immunologically distinct groups in lupus nephritis patients based on blood immunophenotyping, correlating with histopathology, treatment response, and renal outcomes.

The paper defines the chromatin landscape of healthy and injured kidney cells using multi-omics data, identifying regulatory elements and transcription factor networks involved in injury response.

The paper creates a high-resolution cellular atlas of healthy and injured kidney cell states and niches using single-cell and spatial technologies, identifying molecular signatures and pathways related to kidney injury.

The paper uses plasma proteomics to identify tissue-specific cell death and cell-cell interaction mediators in severe COVID-19 patients, linking them to survival outcomes and viral infection effects.

The paper identifies eQTLs in glomerular and tubulointerstitial kidney tissues from nephrotic syndrome patients, finds tissue-specific eQTLs, and integrates them with a GWAS to identify associated genes.