Lung adventitial fibroblasts support type 2 Tregs to shape the response to influenza infection
Anthony Chang, Joanna Balcerek, Sofia E. Caryotakis, Kennedi B. Pyper, Peri R. Matatia, Elina B. Wells, Tatsuya Tsukui, Nathan A. Ewing-Crystal, Eric Dean Merrill, Nicholas M. Mroz, Madelene W. Dahlgren, Kelly M. Cautivo, Marcela T Taruselli, Hiromi Nakao-Inoue, Anna Victoria Molofsky, , Ari B. Molofsky
The paper identifies IAV-driven fibroblast states and shows that loss of TGFβ signaling enhances immuno-modulatory fibroblasts, supporting T2-Tregs to improve lung outcomes.
bioRxiv · Apr 9, 2026 · PreprintImmunology