In vivo multiomic Perturb-seq with enhanced nuclear gRNA capture
Xinhe Zheng, Jiwen Li, Kwanho Kim, Sean Simmons, Ziyan Zhao, Melodi Tastemel, Nhan Huynh, Huixian Qiu, Juntong Ye, Cassandra M Whte, Joshua Z. Levin, Xin Jin
This paper develops an in vivo multiomic Perturb-seq platform to improve gRNA recovery and applies it to study neurodevelopmental disorder risk genes in the cortex.
bioRxiv · Mar 17, 2026 · PreprintGenomics