Author

Melodi Tastemel

University of California San DiegoORCID 0009-0009-6619-1907Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Adam JussilaiD· 1 shared Ami PantiD· 1 shared Bharath SaravananiD· 1 shared Bing ReniD· 1 shared Cassandra M WhteiD· 1 shared Ethan J. ArmandiD· 1 shared Femke W. Munting· 1 shared Hui HuangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperGenomics

Adam JussilaORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintMar 17, 2026

In vivo multiomic Perturb-seq with enhanced nuclear gRNA capture

Xinhe Zheng, Jiwen Li, Kwanho Kim…·Xin Jin

This paper develops an in vivo multiomic Perturb-seq platform to improve gRNA recovery and applies it to study neurodevelopmental disorder risk genes in the cortex.

5 citations

mousescRNA-seq

𝕏 PostBluesky

Molecular BiologyNature GeneticsPeer-reviewedFeb 16, 2026

Genome-wide in vivo dynamics of cohesin-mediated loop extrusion and its role in transcription activation

Tessa M. Popay, Ami Pant, Femke W. Munting…·Jesse R. Dixon

This study investigates cohesin-mediated loop extrusion dynamics and its role in transcription activation by depleting NIPBL in vivo.

15 citationstop 1%

humanChIP-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintFeb 21, 2025

Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion Machinery

Melodi Tastemel, Adam Jussila, Bharath Saravanan…·Bing Ren

The paper investigates how chromatin architecture, mediated by histone modifiers and loop-extrusion machinery, influences gene regulation in mouse embryonic stem cells under different conditions.

DOI 10.1101/2025.02.21.639596

mouseChIP-seq

𝕏 PostBluesky