Author

Ziyan Zhao

Howard Hughes Medical InstitutePrimary ORCID profile (0009-0007-9988-7738 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Ziyan ZhaoiD1 paper · Duke Kunshan University

Biology Disciplines

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Genomics· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Huixian Qiu· 2 shared Nhan HuynhiD· 2 shared Xin JiniD· 2 shared Xinhe ZhengiD· 2 shared Alexander SuniD· 1 shared Cassandra M WhteiD· 1 shared Chang-Ting Chen· 1 shared Cindy T. J. van VelthoveniD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersGenomics

Huixian Qiu

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Towards autonomous biology: Compiler-Verified Protocols as a Foundation for Real World AI Execution

Renjian Song, Yaokai Fu, Ziyan Zhao, Jigang Yu, Qing Yuan, Chang-Ting Chen

This paper introduces BPL, a compiler-verified language for biology protocols, and demonstrates its ability to convert natural language SOPs into reproducible, physically valid protocols with high fidelity.

bioRxiv · May 7, 2026 · PreprintSynthetic Biology

Genome-scale functional mapping of the mammalian whole brain with in vivo Perturb-seq

Tuo Shi, Maria V. Korshunova, Seoyeon Kim, David DeTomaso, Xinhe Zheng, Lavanya Vishvanath, Thokozile Nyasulu, Nhan Huynh, Alexander Sun, Patrick C. Thompson, Yifan Zhang, Emilie M. Wigdor, Narjes Rohani, Salma Ali, Huixian Qiu, , Xin Jin

The paper maps gene expression responses to loss of 1,947 disease-associated genes across the mouse brain using Perturb-seq, revealing cell-type-specific essentiality and transcriptional programs.

bioRxiv · Mar 18, 2026 · PreprintGenomics

In vivo multiomic Perturb-seq with enhanced nuclear gRNA capture

Xinhe Zheng, Jiwen Li, Kwanho Kim, Sean Simmons, Ziyan Zhao, Melodi Tastemel, Nhan Huynh, Huixian Qiu, Juntong Ye, Cassandra M Whte, Joshua Z. Levin, Xin Jin

This paper develops an in vivo multiomic Perturb-seq platform to improve gRNA recovery and applies it to study neurodevelopmental disorder risk genes in the cortex.

bioRxiv · Mar 17, 2026 · PreprintGenomics