Long Gao

The paper identifies cell-type-specific transcription factors that bind rDNA and regulate rRNA transcription, showing CEBPA's role in promoting Pol I occupancy and rRNA synthesis in myeloid progenitors.

This study shows chronic ER stress induces β-cell plasticity, but excessive stress leads to identity loss and is linked to T1D progression.

The paper uses 3D chromatin maps to identify cell-type-specific regulatory architecture of type 2 diabetes risk by analyzing pancreatic cell types.

This study shows that FoxA factors are essential for maintaining the hepatic gene regulatory network in adult mice, as their loss leads to rapid hepatocyte dedifferentiation and lethality.

Multi-ethnic type 2 diabetes (T2D) meta-analysis of 228,499 cases and 1,178,783 controls finds 318 previously unreported loci, 804 expression-colocalized genes, and 13 SNP-by-T2D vascular-outcome interactions.

The paper defines the transcriptomes and epigenomes of key developmental stages of HSC ontogeny in mice and constructs transcriptional regulatory networks using computational methods.