Author

Justyn Fine

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Organism:human· 2 Approach:biophysical modeling· 1 Assay:protein structure· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Jamie B. SpangleriD· 3 shared Andrei Thomas‐TikhonenkoiD· 2 shared Annette CastroiD· 2 shared Katharina E. HayeriD· 2 shared Priyanka D. SehgaliD· 2 shared Zhiwei AngiD· 2 shared Adam Cain ResnickiD· 1 shared Adanna Mogbo· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

Jamie B. SpanglerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target

Zhiwei Ang, Annette Castro, Luca Paruzzo, Carolin Schimdt, Zainul S. Hasanali, Katharina E. Hayer, Federico Stella, Samantha S. Soldan, Manuel Torres-Diz, Christopher Kwok, Patricia King Sainos, Kayla W. Ji, Patrick J. Krohl, Justyn Fine, Priyanka D. Sehgal, , Andrei Thomas‐Tikhonenko

The paper identifies P2RX5 as a new B-cell surface marker and multi-lineage immunotherapy target, showing its expression in B-cell malignancies and T-cell leukemia, and demonstrating the efficacy of P2RX5-directed therapies.

bioRxiv · Jan 26, 2026 · PreprintCancer Biology

NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas

Priyanka D. Sehgal, Ammar S. Naqvi, Makenna Higgins, Jia‐Geng Liu, Kyra Harvey, Julien Jarroux, Tae Woo Kim, Berk Mankaliye, Pamela Mishra, Grace Watterson, Justyn Fine, Jacinta Davis, Katharina E. Hayer, Annette Castro, Adanna Mogbo, , Andrei Thomas‐Tikhonenko

The paper identifies a NRCAM proteoform with skipped microexons as a targetable surface antigen in pHGG and demonstrates its utility in immunotherapy.

Cell Reports · Aug 1, 2025Peer-reviewedCancer Biology

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

Edin Muratspahić, David Feldman, David E. Kim, Xiangli Qu, Ana-Maria Bratovianu, Paula Rivera-Sánchez, Jan Hendrik Voss, Emil Peter Thrane Hertz, Mads Jeppesen, Federica Dimitri, Kensuke Sakamoto, Amrita Nallathambi, Pia Peceli, Jianjun Cao, Brian P. Cary, , David A. Baker

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

bioRxiv · Mar 23, 2025 · PreprintBioengineering