Antibody-based immunotherapy targeting FAM19A5 reverses synaptic loss and improves cognitive function in Alzheimer's disease.
Hanbyul Kim, Sangjin Yoo, Hoyun Kwak, Shi‐Xun Ma, Ryunhee Kim, Minhyeok Lee, Nui Ha, Soonil Pyo, Soon-Gu Kwon, Eun-Ho Cho, Sang‐Myeong Lee, Juwon Jang, Won‐Kyum Kim, Hae‐Chul Park, Minkyung Baek, , Jae Young Seong
This paper shows that targeting FAM19A5 with a monoclonal antibody improves synaptic function and cognition in Alzheimer's disease models.
bioRxiv · Nov 22, 2023 · PreprintNeuroscience