Author

Shi‐Xun Ma

Johns Hopkins UniversityORCID 0000-0002-4208-9248Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Hoyun KwakiD· 2 shared Jae Young SeongiD· 2 shared Jong‐Ik HwangiD· 2 shared Sangjin YooiD· 2 shared Anu Shahapal· 1 shared Eun-Ho Cho· 1 shared Hae‐Chul ParkiD· 1 shared Han Seok KoiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersNeuroscience

Hoyun KwakORCID

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3 papers

Recent·Most cited

Partial FAM19A5 Deficiency in Mice Leads to Disrupted Spine Maturation, Hyperactivity and Altered Fear Response

Anu Shahapal, Sumi Park, Sangjin Yoo, Shi‐Xun Ma, Jong-Ha Lee, Hoyun Kwak, Jong‐Ik Hwang, Jae Young Seong

This study shows that partial FAM19A5 deficiency in mice causes spine maturation issues, hyperactivity, and altered fear responses.

PLoS ONE · Aug 5, 2025Peer-reviewedNeuroscience

Antibody-based immunotherapy targeting FAM19A5 reverses synaptic loss and improves cognitive function in Alzheimer's disease.

Hanbyul Kim, Sangjin Yoo, Hoyun Kwak, Shi‐Xun Ma, Ryunhee Kim, Minhyeok Lee, Nui Ha, Soonil Pyo, Soon-Gu Kwon, Eun-Ho Cho, Sang‐Myeong Lee, Juwon Jang, Won‐Kyum Kim, Hae‐Chul Park, Minkyung Baek, , Jae Young Seong

This paper shows that targeting FAM19A5 with a monoclonal antibody improves synaptic function and cognition in Alzheimer's disease models.

bioRxiv · Nov 22, 2023 · PreprintNeuroscience

Linking Gba1 E326K mutation to microglia activation and mild age-dependent dopaminergic Neurodegeneration

Sin Ho Kweon, Hye Guk Ryu, Hyeonwoo Park, Saebom Lee, Namshik Kim, Seung‐Hwan Kwon, Shi‐Xun Ma, Sangjune Kim, Han Seok Ko

This study investigates the effects of Gba1 E326K mutation in mice, showing increased microglia activation, neuroinflammation, and dopaminergic neurodegeneration.

bioRxiv · Sep 14, 2023 · PreprintNeuroscience