Author

Jong‐Ik Hwang

Korea UniversityORCID 0000-0002-0729-1782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Hoyun KwakiD· 4 shared Jae Young SeongiD· 4 shared Sangjin YooiD· 4 shared Anu Shahapal· 3 shared Minhyeok LeeiD· 3 shared Eun-Ho Cho· 2 shared Nui HaiD· 2 shared Sang‐Myeong LeeiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Hoyun KwakORCID

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Author profile →

4 papers

Recent·Most cited

Partial FAM19A5 Deficiency in Mice Leads to Disrupted Spine Maturation, Hyperactivity and Altered Fear Response

Anu Shahapal, Sumi Park, Sangjin Yoo, Shi‐Xun Ma, Jong-Ha Lee, Hoyun Kwak, Jong‐Ik Hwang, Jae Young Seong

This study shows that partial FAM19A5 deficiency in mice causes spine maturation issues, hyperactivity, and altered fear responses.

PLoS ONE · Aug 5, 2025Peer-reviewedNeuroscience

Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knock-out, and LacZ knock-in mice.

Hoyun Kwak, Eun-Ho Cho, Eun Bee Cho, Yoo-Na Lee, Anu Shahapal, Hyo Jeong Yong, Arfaxad Reyes‐Alcaraz, Yongwoo Jeong, Yerim Lee, Minhyeok Lee, Nui Ha, Sitaek Oh, Jae Keun Lee, Won Suk Lee, Won Kyum Kim, , Jae Young Seong

This study examines FAM19A5 expression and function in mice, finding low peripheral levels and no significant interaction with S1PR2.

Molecules and Cells · Oct 18, 2024Peer-reviewedGenetics

FAM19A5 Deficiency Mitigates the Aβ Plaque Burden and Improves Cognition in Mouse Models of Alzheimer's Disease

Sumi Park, Anu Shahapal, Sangjin Yoo, Hoyun Kwak, Minhyeok Lee, Sang‐Myeong Lee, Jong‐Ik Hwang, Jae Young Seong

This study shows that reducing FAM19A5 in Alzheimer's mouse models lowers Aβ plaques and improves cognition, suggesting anti-FAM19A5 antibodies as a potential therapy.

Experimental Neurobiology · Aug 31, 2024Peer-reviewedNeuroscience

Antibody-based immunotherapy targeting FAM19A5 reverses synaptic loss and improves cognitive function in Alzheimer's disease.

Hanbyul Kim, Sangjin Yoo, Hoyun Kwak, Shi‐Xun Ma, Ryunhee Kim, Minhyeok Lee, Nui Ha, Soonil Pyo, Soon-Gu Kwon, Eun-Ho Cho, Sang‐Myeong Lee, Juwon Jang, Won‐Kyum Kim, Hae‐Chul Park, Minkyung Baek, , Jae Young Seong

This paper shows that targeting FAM19A5 with a monoclonal antibody improves synaptic function and cognition in Alzheimer's disease models.

bioRxiv · Nov 22, 2023 · PreprintNeuroscience