Jae Young Seong

Partial FAM19A5 Deficiency in Mice Leads to Disrupted Spine Maturation, Hyperactivity and Altered Fear Response

This study shows that partial FAM19A5 deficiency in mice causes spine maturation issues, hyperactivity, and altered fear responses.

Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knock-out, and LacZ knock-in mice.

This study examines FAM19A5 expression and function in mice, finding low peripheral levels and no significant interaction with S1PR2.

FAM19A5 Deficiency Mitigates the Aβ Plaque Burden and Improves Cognition in Mouse Models of Alzheimer's Disease

This study shows that reducing FAM19A5 in Alzheimer's mouse models lowers Aβ plaques and improves cognition, suggesting anti-FAM19A5 antibodies as a potential therapy.

Antibody-based immunotherapy targeting FAM19A5 reverses synaptic loss and improves cognitive function in Alzheimer's disease.

This paper shows that targeting FAM19A5 with a monoclonal antibody improves synaptic function and cognition in Alzheimer's disease models.

FAM19A5l affects mustard oil-induced peripheral nociception in zebrafish

This study identifies FAM19A5l in zebrafish as a regulator of mustard oil-induced nociception by modulating TRPA1b and NGFa expression.