Author

Sang‐Myeong Lee

ORCID 0000-0002-3624-3392Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Hoyun KwakiD· 2 shared Jae Young SeongiD· 2 shared Jong‐Ik HwangiD· 2 shared Minhyeok LeeiD· 2 shared Sangjin YooiD· 2 shared Anu Shahapal· 1 shared Eun-Ho Cho· 1 shared Hae‐Chul ParkiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Hoyun KwakORCID

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2 papers

Recent·Most cited

FAM19A5 Deficiency Mitigates the Aβ Plaque Burden and Improves Cognition in Mouse Models of Alzheimer's Disease

Sumi Park, Anu Shahapal, Sangjin Yoo, Hoyun Kwak, Minhyeok Lee, Sang‐Myeong Lee, Jong‐Ik Hwang, Jae Young Seong

This study shows that reducing FAM19A5 in Alzheimer's mouse models lowers Aβ plaques and improves cognition, suggesting anti-FAM19A5 antibodies as a potential therapy.

Experimental Neurobiology · Aug 31, 2024Peer-reviewedNeuroscience

Antibody-based immunotherapy targeting FAM19A5 reverses synaptic loss and improves cognitive function in Alzheimer's disease.

Hanbyul Kim, Sangjin Yoo, Hoyun Kwak, Shi‐Xun Ma, Ryunhee Kim, Minhyeok Lee, Nui Ha, Soonil Pyo, Soon-Gu Kwon, Eun-Ho Cho, Sang‐Myeong Lee, Juwon Jang, Won‐Kyum Kim, Hae‐Chul Park, Minkyung Baek, , Jae Young Seong

This paper shows that targeting FAM19A5 with a monoclonal antibody improves synaptic function and cognition in Alzheimer's disease models.

bioRxiv · Nov 22, 2023 · PreprintNeuroscience