T. Maerz

Synovial macrophage diversity and activation of M-CSF signaling in post-traumatic osteoarthritis

This study identifies synovial macrophage subpopulations and their regulation by M-CSF signaling in a mouse model of post-traumatic osteoarthritis.

Albumin-binding RNAi Conjugate for Carrier Free Treatment of Arthritis

This paper develops an MMP13-targeting siRNA conjugate that preferentially accumulates in arthritic joints, reducing disease markers and outperforming current treatments.

Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury

This study shows male mice have worse joint damage and persistent synovial inflammation after ACLR injury compared to females.

Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 to drive osteoarthritis

This study identifies distinct synovial fibroblast subsets in PTOA and shows that Prg4hi fibroblasts secrete Rspo2 to drive pathological crosstalk.

Early Patellofemoral Cartilage and Bone Degeneration in a Rat Model of Noninvasive Anterior Cruciate Ligament Rupture

This study shows ACL rupture in rats causes early patellofemoral cartilage degeneration and bone remodeling, indicating the model's utility for studying PTOA in this joint.

Traumatic Joint Injury Induces Acute Catabolic Bone Turnover Concurrent with Articular Cartilage Damage in a Rat Model of Post-Traumatic Osteoarthritis

This study shows that traumatic joint injury in rats causes acute bone catabolism and cartilage damage, with reduced bone formation and increased osteoclast activity.