K. A. McDonald

Biomechanical effects of adding an articulating toe joint to a passive foot prosthesis for incline and decline walking

This study evaluates the biomechanical effects of an articulating toe joint in a passive foot prosthesis on slope walking, finding small kinematic and kinetic changes and user-specific preferences.

Humans trade-off whole-body energy cost to avoid overburdening muscles while walking

The paper decouples metabolic and muscle activation costs in human walking, finding participants prioritized fatigue avoidance over energy minimization.

Production of novel Spike truncations in Chinese hamster ovary cells

The paper improves Spike protein expression in CHO cells by developing truncations that outperform full-length Spike and RBD in expression levels and antibody binding.

Functionalizing silica sol-gel with entrapped plant virus-based immunosorbent nanoparticles

The paper immobilizes a virus-based nanomaterial in silica sol-gel to create a stable, reusable system for antibody binding and elution in biosensing applications.

Affinity sedimentation and magnetic separation with plant-made immunosorbent nanoparticles for therapeutic protein purification

This paper develops plant-made immunosorbent nanoparticles for therapeutic protein purification, demonstrating enhanced binding capacity and introducing magnetic separation to improve efficiency.

Evaluating the cost of pharmaceutical purification for a long-duration space exploration medical foundry

This study evaluates pharmaceutical purification costs for space missions using the ESM metric, comparing biotic and abiotic methods for monoclonal antibody purification.

Analysis of variability of functionals of recombinant protein production trajectories based on limited data

The paper develops a bootstrap-based method to infer variability in functionals of protein production trajectories from limited data, applied to time-to-harvest and maximal productivity.

Development and simulation of fully glycosylated molecular models of ACE2-Fc fusion proteins and their interaction with the SARS-CoV-2 spike protein binding domain

The paper develops and simulates fully glycosylated ACE2-Fc fusion proteins and their interaction with SARS-CoV-2 spike protein RBD, showing glycan effects on conformation and optimizing glycosylation modeling algorithms.