P. S. Shah

Computational evaluation of light propagation in cylindrical bioreactors for optogenetic mammalian cell cultures

The paper evaluates light propagation in cylindrical bioreactors to determine the scalability of optogenetic control in mammalian cell cultures.

Hippo Signaling Pathway Activation during SARS-CoV-2 Infection Contributes to Host Antiviral Response

This study identifies Hippo signaling pathway activation as an antiviral response to SARS-CoV-2 infection and shows pharmacological targeting of the pathway can reduce virus replication.

Production of novel Spike truncations in Chinese hamster ovary cells

The paper improves Spike protein expression in CHO cells by developing truncations that outperform full-length Spike and RBD in expression levels and antibody binding.

Nuclear dengue virus NS5 antagonizes expression of PAF1-dependent immune response genes

This paper shows that DENV NS5 interacts with PAF1C to suppress immune response genes, and disrupting this interaction restores PAF1-dependent gene expression.

Zika Virus Infection Prevents Host mRNA Nuclear Export by Disrupting UPF1 Function

This study shows ZIKV infection disrupts UPF1 function, leading to nuclear mRNA accumulation and impaired neural progenitor cell function.

Transient light-activated gene expression in Chinese hamster ovary cells

This study evaluates light-activated gene expression in CHO cells using optogenetics, showing transient activation but limited stable expression.

The cellular NMD pathway restricts Zika virus infection and is targeted by the viral capsid protein

This study shows that ZIKV infection disrupts the NMD pathway by interacting with UPF1 via its capsid protein, enhancing viral infection and contributing to neuropathology.