Author

K. Artavanis-Tsakonas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 4 Organism:plant (other)· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Smith· 2 shared D. B. Ascher· 2 shared A. A. Vinogradov· 1 shared A. Protasio· 1 shared B. Nash· 1 shared C. J. Sutherland· 1 shared G. J. van der Heden van Noort· 1 shared G. Kelly· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersMicrobiology

C. Smith

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Targeting the Plasmodium falciparum UCHL3 ubiquitin hydrolase using chemically constrained peptides

H. R. King, M. Bycroft, T.-B. Nguyen, G. Kelly, A. A. Vinogradov, P. J. Rowling, K. Stott, D. B. Ascher, H. Suga, L. S. Itzhaki, K. Artavanis-Tsakonas

This study identifies chemically constrained peptides that inhibit PfUCHL3, a critical deubiquitinating enzyme in Plasmodium falciparum, by blocking substrate binding rather than active site interaction.

bioRxiv · Jan 11, 2024 · PreprintBiophysics

A multistage Plasmodium CRL4-WIG1 ubiquitin ligase is critical for the formation of functional microtubule organisation centres in microgametocytes

R. Rashpa, C. Smith, K. Artavanis-Tsakonas, M. Brochet

This study identifies a CRL4-related ubiquitin ligase in Plasmodium that is critical for microgametocyte formation by regulating proteostasis of ciliary and DNA replication proteins.

bioRxiv · Jul 19, 2023 · PreprintMicrobiology

Large-scale proteomic analysis of T. spiralis muscle-stage ESPs identifies a novel upstream motif for in silico prediction of secreted products

B. Nash, W. F. Gregory, R. R. White, A. Protasio, S. P. Gygi, M. E. Selkirk, M. P. Weekes, K. Artavanis-Tsakonas

This study identifies a novel upstream motif in T. spiralis muscle-stage ESPs that can predict secreted proteins, using proteomic and computational methods.

Frontiers in Parasitology · Jan 25, 2023Peer-reviewedCell Biology

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt ubiquitin hydrolysis

C. Smith, R. Henrici, M. Karpiyevich, M. R. Ansbro, J. Hoshizaki, G. J. van der Heden van Noort, D. B. Ascher, C. J. Sutherland, M. C. S. Lee, K. Artavanis-Tsakonas

The paper investigates mutations in Plasmodium UBP-1 linked to drug resistance and shows how these mutations affect ubiquitin hydrolysis and parasite fitness.

bioRxiv · Sep 15, 2022 · PreprintMicrobiology