Author

M. C. S. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:plant (other)· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

A. F. Cowman· 1 shared A. L. Cheung· 1 shared A. M. Lehane· 1 shared A. S. M. Dennis· 1 shared A. T. Papenfuss· 1 shared B. Y. Zou· 1 shared C. J. Sutherland· 1 shared C. Smith· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMicrobiology

A. F. Cowman

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Drug resistance-associated mutations in Plasmodium UBP-1 disrupt ubiquitin hydrolysis

C. Smith, R. Henrici, M. Karpiyevich, M. R. Ansbro, J. Hoshizaki, G. J. van der Heden van Noort, D. B. Ascher, C. J. Sutherland, M. C. S. Lee, K. Artavanis-Tsakonas

The paper investigates mutations in Plasmodium UBP-1 linked to drug resistance and shows how these mutations affect ubiquitin hydrolysis and parasite fitness.

bioRxiv · Sep 15, 2022 · PreprintMicrobiology

Generation and characterisation of P. falciparum parasites with a G358S mutation in the PfATP4 Na+ pump and clinically relevant levels of resistance to some PfATP4 inhibitors

D. Qiu, J. V. Pei, J. E. O. Rosling, D. Li, Y. Xue, J. S. Penington, K. Kümpornsin, Y. T. V. Aw, J. Y. H. Aw, H. Hasemer, A. S. M. Dennis, M. C. Ridgway, A. T. Papenfuss, M. C. S. Lee, G. G. van Dooren, , A. M. Lehane

This paper shows that a G358S mutation in PfATP4 confers clinically relevant resistance to cipargamin and (+)-SJ733 in P. falciparum parasites.

bioRxiv · Jan 11, 2022Microbiology

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

G. M. LaMonte, D. S. Marapana, N. Gnadig, S. Ottilie, M. R. Luth, T. S. Worgall, F. Rocamora, G. M. Goldgof, R. Mohunlal, T. R. S. Kumar, J. K. Thompson, E. Vigil, J. Yang, D. Hutson, T. Johnson, , E. A. Winzeler

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

bioRxiv · Aug 15, 2019Microbiology