A. F. Read

Reversion to sensitivity explains limited transmission of resistance in a hospital pathogen

The paper investigates how resistance in hospital pathogens reverts to sensitivity when antibiotic pressure is removed, finding that transmitted resistance loses less resistance than de novo resistance.

Comparative Analysis of Multiple Consensus Genomes of the Same Strain of Marek's Disease Virus Reveals Intrastrain Variation

This study compares multiple consensus genomes of the same Marek's Disease Virus strain, revealing intrastrain variation and highlighting the need for multiple genomes to improve interstrain comparisons.

Rising daptomycin resistance in Enterococcus faecium across a hospital system occurred via rampant recurrent evolution and occasional transmission between patients.

This study shows that daptomycin resistance in Enterococcus faecium increased due to recurrent mutations and occasional transmission between patients in a hospital system.

Ion exchange biomaterials to capture daptomycin and prevent resistance evolution in off-target bacterial populations

This study shows ion exchange biomaterials can capture daptomycin in the gut, preventing resistance evolution in off-target bacteria.

Divergent Evolutionary Pathways of Myxoma Virus in Australia: Virulence Phenotypes in Susceptible and Partially Resistant Rabbits Indicate Possible Selection for Transmissibility

This study examines the evolution of myxoma virus in Australian rabbits through experimental infections, revealing diverse virulence phenotypes and suggesting selection for transmissibility over inflammation.

Oral cholestyramine prevents enrichment of diverse daptomycin-resistance mutations in intestinal Enterococcus faecium

This study shows that cholestyramine prevents the enrichment of daptomycin-resistant Enterococcus faecium mutations in the gut when administered before or after daptomycin treatment.

Genetic determinants of antibiotic resistance and the evolution of trade-offs during adaptation in a single patient

This study tracks genetic and phenotypic changes in antibiotic resistance in a single patient's infection over time, revealing no pan-resistant isolate and complex patterns of collateral sensitivity and combination therapy responses.

Modifying adaptive therapy to enhance competitive suppression

This paper evaluates adaptive therapy for cancer, identifies three modifications to enhance competitive suppression, and shows they delay tumor progression and expand patient eligibility.

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

This study shows that cholestyramine, when used with daptomycin, reduces the spread of antibiotic-resistant Enterococcus faecium in mice.

The effect of drug dose and timing of treatment on the emergence of drug resistance in vivo in a malaria model

This study investigates how drug dose and timing affect resistance emergence in a malaria model, finding that higher doses can increase resistance and timing impacts resistance risk non-linearly.

Breaking down defenses: Quantitative analysis of malaria infection dynamics reveals distinct immune defense strategies

This study quantifies immune defense strategies against malaria by analyzing parasite and RBC dynamics, revealing coordinated resource-directed strategies that benefit the host.

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

This study shows that maintaining large populations of drug-sensitive bacteria can delay the rise of drug-resistant bacteria using containment strategies.

Punctuated evolution of myxoma virus: rapid and disjunct evolution of a recent viral lineage in Australia

This paper shows that Myxoma virus in Australia experienced a sudden evolutionary change with a faster mutation rate and disrupted clock-like evolution between 1996 and 2012, likely due to environmental changes affecting rabbit populations.

Modeling Marek’s disease virus transmission: a framework for evaluating the impact of farming practices and evolution on disease

The paper develops and validates mathematical models of Marek’s disease virus transmission using farm data to evaluate how farming practices and virus evolution impact disease.