Author

P. Lowenstein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

F. Nunez· 2 shared M. G. Castro· 2 shared R. Ravindran· 2 shared S. Carney· 2 shared A. Chinnaiyan· 1 shared A. Comba· 1 shared A. Taher· 1 shared B. Mullan· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCancer Biology

F. Nunez

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Author profile →

4 papers

Recent·Most cited

Scale-free correlations and criticality in an experimental model of brain cancer

K. B. Wood, A. Comba, S. Motsch, T. S. Grigera, P. Lowenstein

The paper studies collective motion of glioblastoma cells and finds scale-free correlations suggesting the system is near a critical point.

bioRxiv · Jul 10, 2022 · PreprintBiophysics

Therapeutic reversal of prenatal pontine ID1 signaling in DIPG

V. N. Yadav, M. K. Harris, D. Messinger, C. Thomas, J. R. Cummings, T. Yang, R. Woo, R. Siddaway, M. Burkert, S. Stallard, T. Qin, B. Mullan, R. Siada, R. Ravindran, M. Niculcea, , C. Koschmann

This study identifies ID1 upregulation in DIPG tumor cells and shows that CBD can reduce ID1-driven invasiveness in vitro and in vivo.

bioRxiv · May 10, 2021 · PreprintCancer Biology

G-CSF SECRETED BY EPIGENETICALLY REPROGRAMMED MUTANT IDH1 GLIOMA STEM CELLS REVERSES THE MYELOID CELLS'-MEDIATED IMMUNOSUPPRESSIVE TUMOR MICROENVIRONMENT

M. S. Alghamri, R. Avvari, R. Thalla, N. Kamran, L. Zhang, M. Ventosa, A. Taher, S. Faisal, F. Nunez, M. Garcia-Fabiani, S. Haase, S. Carney, D. Orringer, S. Hervey-Jumper, J. Heth, , M. G. Castro

The paper shows that mIDH1 glioma stem cells secrete G-CSF, which reprograms myeloid cells to become non-immunosuppressive, altering the tumor microenvironment.

bioRxiv · Jul 22, 2020 · PreprintCancer Biology

Therapeutic efficacy of an immune stimulatory gene therapy strategy in a mouse model of high grade brainstem glioma

F. M. Mendez, P. Kadiyala, F. J. Nunez, S. Carney, F. Nunez, J. C. Gauss, R. Ravindran, S. Pawar, M. Edwards, P. Lowenstein, M. G. Castro

This paper tests an immune-stimulatory gene therapy in a mouse model of DIPG, showing increased survival and anti-tumor immunity through adenoviral delivery of TK and Flt3L.

bioRxiv · Nov 18, 2019 · PreprintCancer Biology