Author

K. Beebe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

L. Neckers· 2 shared A. Joshi· 1 shared D. Picard· 1 shared F. T. F. Tsai· 1 shared G. Segala· 1 shared H. Schwartz· 1 shared H. Williams· 1 shared J. Dai· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCell Biology

L. Neckers

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis

A. Joshi, J. Dai, J. Lee, N. Mohammadi Ghahhari, G. Segala, K. Beebe, F. T. F. Tsai, L. Neckers, D. Picard

This study shows TRAP1 forms an OXPHOS-regulated tetramer and is essential for maintaining mitochondrial metabolic homeostasis by modulating OXPHOS and interacting with mitochondrial chaperones.

bioRxiv · Jun 21, 2019Cell Biology

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

T. Kijima, T. L. Prince, M. Tigue, K. Yim, H. Schwartz, K. Beebe, S. Lee, M. Budzynski, H. Williams, J. Trepel, L. Sistonen, S. K. Calderwood, L. Neckers

This study shows HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction, revealing a noncanonical role for HSP90 in modulating HSF1 activity by removing HSF1 trimers from DNA.

bioRxiv · Mar 2, 2018Biochemistry