Author

L. Neckers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

K. Beebe· 2 shared A. Al-Motawa· 1 shared A. Cross· 1 shared A. Joshi· 1 shared A. R. Frank· 1 shared B. Blagg· 1 shared D. G. McFadden· 1 shared D. Picard· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

K. Beebe

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid

A. R. Frank, V. Li, S. D. Shelton, J. Kim, G. M. Stott, L. Neckers, Y. Xie, N. S. Williams, P. Mishra, D. G. McFadden

This study shows that mitochondrial complex I defects in thyroid cancer drive reliance on aerobic fermentation, which can be targeted with lactate dehydrogenase inhibitors.

bioRxiv · Aug 16, 2022Cancer Biology

HSP90 inhibitors reduce cholesterol storage in Niemann-Pick type C1 mutant fibroblasts

N. H. Pipalia, S. Z. Saad, K. Subramanian, A. Cross, A. Al-Motawa, K. K. Garg, B. Blagg, L. Neckers, P. Helquist, O. Wiest, D. S. Ory, F. R. Maxfield

This study shows HSP90 inhibitors reduce cholesterol storage in NPC1 mutant fibroblasts by enhancing mutant NPC1 protein delivery to lysosomes.

bioRxiv · Apr 22, 2021Cell Biology

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in maintaining mitochondrial metabolic homeostasis

A. Joshi, J. Dai, J. Lee, N. Mohammadi Ghahhari, G. Segala, K. Beebe, F. T. F. Tsai, L. Neckers, D. Picard

This study shows TRAP1 forms an OXPHOS-regulated tetramer and is essential for maintaining mitochondrial metabolic homeostasis by modulating OXPHOS and interacting with mitochondrial chaperones.

bioRxiv · Jun 21, 2019Cell Biology

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

T. Kijima, T. L. Prince, M. Tigue, K. Yim, H. Schwartz, K. Beebe, S. Lee, M. Budzynski, H. Williams, J. Trepel, L. Sistonen, S. K. Calderwood, L. Neckers

This study shows HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction, revealing a noncanonical role for HSP90 in modulating HSF1 activity by removing HSF1 trimers from DNA.

bioRxiv · Mar 2, 2018Biochemistry