Author

K. Berndsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

D. R. Alessi· 3 shared A. Knebel· 2 shared F. Tonelli· 2 shared P. Lis· 2 shared S. R. Pfeffer· 2 shared A. R. Khan· 1 shared D. Waschbüsch· 1 shared H. S. Dhekne· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

D. R. Alessi

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Author profile →

3 papers

Recent·Most cited

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

S. S. Khan, Y. Sobu, H. S. Dhekne, F. Tonelli, K. Berndsen, D. R. Alessi, S. R. Pfeffer

The paper shows that LRRK2 mutations and PPM1H loss cause cilia loss in neurons and astrocytes, disrupting Hedgehog signaling in the nigral-striatal pathway.

bioRxiv · Mar 2, 2021Cell Biology

Structural basis for the specificity of PPM1H phosphatase for Rab GTPases

D. Waschbüsch, K. Berndsen, P. Lis, A. Knebel, Y. P. Lam, D. R. Alessi, A. R. Khan

This paper identifies the structural basis for PPM1H phosphatase specificity for Rab GTPases, showing that a flap domain enables recognition of phosphorylated substrates.

bioRxiv · Feb 17, 2021Biochemistry

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

K. Berndsen, P. Lis, W. Yeshaw, P. S. Wawro, R. S. Nirujogi, M. Wightman, T. Macartney, M. Dorward, A. Knebel, F. Tonelli, S. R. Pfeffer, D. R. Alessi

This study identifies PPM1H as a phosphatase that counteracts LRRK2 signaling by dephosphorylating Rab proteins, suggesting it as a potential therapeutic target for Parkinson's disease.

bioRxiv · Jul 22, 2019Biochemistry