Author

P. S. Wawro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. R. Pfeffer· 3 shared H. S. Dhekne· 2 shared A. Adhikari· 1 shared A. Knebel· 1 shared C. Y. Chiang· 1 shared D. R. Alessi· 1 shared F. Tonelli· 1 shared K. Berndsen· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

S. R. Pfeffer

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Author profile →

3 papers

Recent·Most cited

Localization of PPM1H phosphatase tunes Parkinsons disease-linked LRRK2 kinase-mediated Rab GTPase phosphorylation and ciliogenesis

W. M. Yeshaw, A. Adhikari, C. Y. Chiang, H. S. Dhekne, P. S. Wawro, S. R. Pfeffer

This paper shows that PPM1H phosphatase localization affects its ability to dephosphorylate Rab GTPases, influencing ciliogenesis and membrane trafficking.

Proceedings of the National Academy of Sciences · Oct 27, 2023Peer-reviewedCell Biology

Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2

Y. Sobu, P. S. Wawro, H. S. Dhekne, S. R. Pfeffer

This study shows that pathogenic LRRK2 mutations reduce ciliation probability by blocking TTBK2 recruitment to the mother centriole, leading to ciliary decapitation in response to serum addition.

bioRxiv · Apr 7, 2020Cell Biology

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

K. Berndsen, P. Lis, W. Yeshaw, P. S. Wawro, R. S. Nirujogi, M. Wightman, T. Macartney, M. Dorward, A. Knebel, F. Tonelli, S. R. Pfeffer, D. R. Alessi

This study identifies PPM1H as a phosphatase that counteracts LRRK2 signaling by dephosphorylating Rab proteins, suggesting it as a potential therapeutic target for Parkinson's disease.

bioRxiv · Jul 22, 2019Biochemistry