Murine Norovirus infection results in anti-inflammatory response downstream of amino acids depletion in macrophages
M. Brocard, J. Lu, B. S. Hall, K. Borah, C. Moller-Levet, F. Sorgeloos, D. Beste, I. G. Goodfellow, N. Locker
This study shows that murine norovirus induces metabolic stress in macrophages, leading to anti-inflammatory responses through amino acid depletion and GCN2/ATF2 signaling, rather than a typical innate immune response.
bioRxiv · Apr 22, 2021Microbiology