Author

R. Lahiri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. G. Coyne· 1 shared A. J. Whitehouse· 1 shared B. Bonde· 1 shared B. Bryson· 1 shared B. J. A. Silva· 1 shared B. R. Bloom· 1 shared C. Abell· 1 shared D. L. Williams· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperBiochemistry

A. G. Coyne

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Author profile →

3 papers

Recent·Most cited

GSMN-ML- a genome scale metabolic network reconstruction of the obligate human pathogen Mycobacterium leprae

K. Borah, J. Kearney, R. Banerjee, P. Vats, H. Wu, S. Dahale, S. Manjari, R. Joshi, B. Bonde, O. Ojo, R. Lahiri, D. Williams, J. McFadden

This paper reconstructs a genome-scale metabolic network for Mycobacterium leprae to study its metabolism and identify potential drug targets.

bioRxiv · Oct 25, 2019Microbiology

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

S. E. Thomas, A. J. Whitehouse, K. Brown, J. M. Belardinelli, R. Lahiri, M. D. J. Libardo, P. Gupta, S. Malhotra, H. I. M. Boshoff, M. Jackson, C. Abell, A. G. Coyne, T. L. Blundell, R. A. Floto, V. Mendes

This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.

bioRxiv · May 19, 2019Biochemistry

Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response

D. Montoya, P. R. Andrade, B. J. A. Silva, R. M. B. Teles, B. Bryson, S. Sadanand, T. Noel, J. Lu, E. Sarno, K. B. Arnvig, D. Young, R. Lahiri, D. L. Williams, S. Fortune, B. R. Bloom, , R. L. Modlin

The paper uses dual RNAseq to analyze leprosy lesions, linking bacterial states to host immune responses through type I IFNs and antibody pathways.

bioRxiv · Jun 22, 2018Microbiology