Author

I. G. Goodfellow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Immunology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 10 Organism:human· 5 Research Focus:cell type annotation· 4 Assay:proteomics· 4 Assay:bulk RNA-seq· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

M. Hosmillo· 4 shared E. Emmott· 3 shared F. Sorgeloos· 3 shared A. S. Jahun· 2 shared D. Bhella· 2 shared M. J. Conley· 2 shared Y. Chaudhry· 2 shared A. Albecka· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersMicrobiology

M. Hosmillo

Mutual co-authors in cluster

Author profile →

12 papers

Recent·Most cited

Porcine sapovirus protease controls the innate immune response and targets TBK1

I. Georgana, M. Hosmillo, A. S. Jahun, E. Emmott, F. Sorgeloos, K.-O. Cho, I. G. Goodfellow

This study shows that the porcine sapovirus protease NS6 inhibits type I IFN production by targeting TBK1, revealing a mechanism for immune evasion and establishing a new cell line model for PSaV research.

bioRxiv · Dec 21, 2023Microbiology

Microfluidic antibody profiling after repeated SARS-CoV-2 vaccination links antibody affinity and concentration to impaired immunity and variant escape in patients on anti-CD-20 therapy

A. Priddey, M. X. H. Chen-Xu, D. J. Cooper, S. MacMillan, G. Meisl, C. K. Xu, M. Hosmillo, I. G. Goodfellow, R. Kollyfas, R. Doffinger, J. R. Bradley, I. I. Mohorianu, R. Jones, T. P. J. Knowles, R. Smith, V. Kosmoliaptsis

bioRxiv · Oct 22, 2023Immunology

Zika viruses encode multiple upstream open reading frames in the 5' viral region with a role in neurotropism

C. Lefevre, G. M. Cook, A. M. Dinan, S. Torii, H. Stewart, G. Gibbons, A. S. Nicholson, L. Echavarria-Consuegra, L. W. Meredith, V. Lulla, J. C. Kenyon, I. G. Goodfellow, J. E. Deane, S. C. Graham, A. Lakatos, , N. Irigoyen

This study identifies multiple upstream open reading frames (uORFs) in Zika virus (ZIKV) that influence neurotropism but not mosquito transmission.

bioRxiv · Apr 20, 2023 · PreprintMicrobiology

Human influenza A virus H1N1 1 in marine mammals in California, 2019

M. Plancarte, G. Kovalenko, J. Baldassano, A. L. Ramirez, A. L. Ramirez, S. Carrillo, P. J. Duignan, I. G. Goodfellow, E. Bortz, J. Dutta, H. van Bakel, L. L. Coffey

The paper reports the detection of human H1N1 influenza A virus in northern elephant seals in California in 2019, indicating continued zoonotic transmission from humans to marine mammals.

bioRxiv · Nov 4, 2022 · PreprintMicrobiology

The origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 in the UK

V. Hill, L. du Plessis, T. P. A. Peacock, D. Aggarwal, A. Carabelli, R. Colquhoun, N. Ellaby, E. Gallagher, N. Groves, B. Jackson, J. McCrone, A. N. O'Toole, A. Price, T. Sanderson, E. Scher, , A. Rambaut

This study investigates the origins and molecular evolution of SARS-CoV-2 lineage B.1.1.7 (Alpha) in the UK, finding that a chronically-infected immunocompetent individual likely drove its rapid mutation and spread.

bioRxiv · Mar 8, 2022Evolutionary Biology

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

L. G. Thorne, M. Bouhaddou, A.-K. Reuschl, L. Zuliani-Alvarez, B. J. Polacco, A. Pelin, J. Batra, M. V. X. Whelan, M. Ummadi, A. Roic, J. Turner, K. Obernier, H. Braberg, M. Soucheray, A. L. Richards, , N. J. Krogan

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

bioRxiv · Jun 6, 2021 · PreprintMicrobiology

Murine Norovirus infection results in anti-inflammatory response downstream of amino acids depletion in macrophages

M. Brocard, J. Lu, B. S. Hall, K. Borah, C. Moller-Levet, F. Sorgeloos, D. Beste, I. G. Goodfellow, N. Locker

This study shows that murine norovirus induces metabolic stress in macrophages, leading to anti-inflammatory responses through amino acid depletion and GCN2/ATF2 signaling, rather than a typical innate immune response.

bioRxiv · Apr 22, 2021Microbiology

The cryo-EM structure of vesivirus 2117 highlights functional variations in entry pathways for viruses in different clades of the vesivirus genus.

H. Sutherland, M. J. Conley, E. Emmott, J. Streetley, I. G. Goodfellow, D. Bhella

This study determines the cryo-EM structure of vesivirus 2117, revealing structural differences in the capsid that suggest variations in entry pathways among vesivirus clades.

bioRxiv · Feb 5, 2021Microbiology

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

G. Papa, D. Mallery, A. Albecka, L. Welch, J. Cattin-Ortola, J. Luptak, D. Paul, H. T. McMahon, I. G. Goodfellow, A. P. Carter, S. Munro, L. C. James

bioRxiv · Aug 13, 2020Microbiology

Norovirus replication in human intestinal epithelial cells is restricted by the interferon-induced JAK/STAT signalling pathway and RNA Polymerase II mediated transcriptional responses.

M. T. Hosmillo, Y. Chaudhry, K. Nayak, F. Sorgeloos, B.-K. Koo, A. Merenda, R. Lillestol, L. Drumright, M. Zilbauer, I. G. Goodfellow

This study shows that HuNoV replication in intestinal epithelial cells is restricted by IFN-induced transcriptional responses and that inhibiting these responses enhances viral replication.

bioRxiv · Aug 10, 2019 · PreprintMicrobiology

Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.

H. V. Mears, E. Emmott, Y. Chaudhry, M. Hosmillo, I. G. Goodfellow, T. R. Sweeney

This study shows Ifit1 enhances the interferon response but does not directly inhibit norovirus translation in murine macrophage-like cells.

bioRxiv · Apr 17, 2019Immunology

Calicivirus VP2 forms a portal to mediate endosome escape

M. J. Conley, M. McElwee, L. B. Azmi, M. Gabrielsen, O. Byron, I. G. Goodfellow, D. Bhella

This paper identifies VP2 as a portal structure in caliciviruses that facilitates endosome escape, revealing its role in viral genome release.

bioRxiv · Aug 23, 2018Microbiology