Author

A. Boettcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Organism:plant (other)· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Ahrens· 1 shared A. Feuchtinger· 1 shared A. G. Cino-Ozuna· 1 shared A. Israel· 1 shared A. Kostina· 1 shared A. M. Cypess· 1 shared A. Walch· 1 shared B. S. Saller· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperImmunology

A. Ahrens

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome

E. Neuwirt, G. Magnani, T. Cikovic, A. Kostina, S. Wohrle, S. Flemming, N. J. Fischenich, B. S. Saller, O. Gorka, S. Renner, C. Agarinis, C. Parker, A. Boettcher, C. J. Farady, R. Backofen, , O. Gross

A small molecule screen identifies tyrosine kinase inhibitors that cause lysosomal damage, leading to cell lysis and NLRP3 inflammasome activation via K+ efflux.

bioRxiv · Feb 19, 2022 · PreprintImmunology

Identification and characterization of distinct murine brown adipocyte lineages

S. Ussar, R. Karlina, D. Lutter, V. Miok, D. S. Fischer, I. Altun, T. Schoettl, K. Schorpp, A. Israel, C. Cero, J. W. Johnson, I. Kapser-Fischer, A. Boettcher, S. Keipert, A. Feuchtinger, , A. M. Cypess

The paper identifies and characterizes distinct murine brown adipocyte lineages using single-cell RNA sequencing and functional analysis.

bioRxiv · Aug 24, 2020 · PreprintCell Biology

Novel engraftment and T cell differentiation of human hematopoietic cells in Art-/- IL2RG-/ SCID pigs

A. Boettcher, Y. Li, A. Ahrens, M. Kiupel, K. Byrne, C. Loving, A. G. Cino-Ozuna, J. Wiarda, M. Adur, B. Schultz, J. Swanson, E. Snella, C.-S. Ho, S. Charley, Z. Kiefer, , C. Tuggle

The paper generates a T-B-NK-SCID pig model via CRISPR/Cas9 and demonstrates successful human hematopoietic cell engraftment in blood and lymphoid organs after in utero injection.

bioRxiv · May 2, 2019 · PreprintImmunology