Cancer BiologyScientific ReportsPeer-reviewed
Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages
K. C. M. Gulay, K. Aoshima, N. Maekawa…·T. Kimura
This study identifies ISOS-1 as a syngeneic mouse model for canine hemangiosarcoma and shows that tumor-associated macrophages are M2-polarized and express PD-L1, contributing to immune evasion.
DOI 10.1038/s41598-022-06203-w