S. Konnai

Effect of C-to-T transition at CpG sites on tumor suppressor genes in tumor development in cattle evaluated by somatic mutation analysis in enzootic bovine leukosis

This study identifies somatic mutations in tumor suppressor genes in cattle with enzootic bovine leukosis, highlighting C-to-T transitions at CpG sites and their association with tumor development.

Diagnosis and early prediction of lymphoma using high-throughput clonality analysis of bovine leukemia virus-infected cells

This study evaluates RAISING-CLOVA's ability to detect clonality in BLV-infected cells, showing high sensitivity and specificity in distinguishing EBL from non-EBL cattle and confirming its utility for early detection.

Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages

This study identifies ISOS-1 as a syngeneic mouse model for canine hemangiosarcoma and shows that tumor-associated macrophages are M2-polarized and express PD-L1, contributing to immune evasion.

PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade

This study identifies equine PD-1 and PD-L1 sequences, shows anti-bovine PD-L1 mAbs cross-react with equine PD-L1, and demonstrates PD-L1 blockade enhances Th1 cytokine production in equine immune cells.