N. Maekawa

Diagnosis and early prediction of lymphoma using high-throughput clonality analysis of bovine leukemia virus-infected cells

This study evaluates RAISING-CLOVA's ability to detect clonality in BLV-infected cells, showing high sensitivity and specificity in distinguishing EBL from non-EBL cattle and confirming its utility for early detection.

Hemangiosarcoma cells induce M2 polarization and PD-L1 expression in macrophages

This study identifies ISOS-1 as a syngeneic mouse model for canine hemangiosarcoma and shows that tumor-associated macrophages are M2-polarized and express PD-L1, contributing to immune evasion.

PD-L1 expression in equine malignant melanoma and functional effects of PD-L1 blockade

This study identifies equine PD-1 and PD-L1 sequences, shows anti-bovine PD-L1 mAbs cross-react with equine PD-L1, and demonstrates PD-L1 blockade enhances Th1 cytokine production in equine immune cells.