A. Hirabayashi

Structural basis of Ebola virus nucleocapsid assembly and functions

This study determines the structure of the Ebola virus nucleocapsid using cryo-EM and identifies VP24's role in assembly and function.

Nationwide genome surveillance of carbapenem-resistant Pseudomonas aeruginosa in Japan

This study analyzes genome sequences and antimicrobial resistance patterns of carbapenem-resistant Pseudomonas aeruginosa isolates from Japan, revealing genetic diversity and lower multidrug resistance prevalence compared to other regions.

Strand-biased circularizing integrative elements spread tmexCD-toprJ gene clusters encoding RND-type multidrug efflux pumps by repeated transpositions

The paper identifies a mobile genetic element, SE, that mediates the spread of tmexCD-toprJ gene clusters encoding RND-type multidrug efflux pumps through transposition in bacteria.

Emergence of plasmid-mediated RND-type efflux pump gene cluster tmexCD-toprJ in Shewanella xiamenensis in a water environment

This study identifies a mobile RND-type efflux pump gene cluster tmexCD-toprJ in Shewanella xiamenensis from a water environment, contributing to multidrug resistance.

Emergence of a novel mobile RND-type efflux pump gene cluster, tmexC3D2-toprJ1b, in Pseudomonas species

The paper identifies a novel tmexC3D2-toprJ1b gene cluster conferring tigecycline resistance in Pseudomonas species, acquired via horizontal gene transfer.

A transferable IncC-IncX3 hybrid plasmid co-carrying blaNDM-4, tet(X4), and tmexCD3-toprJ3 confers resistance to carbapenem and tigecycline

The paper identifies a multidrug-resistant plasmid in Klebsiella aerogenes that carries genes for carbapenem and tigecycline resistance and shows its potential for global spread.

On-site genomic epidemiological analysis of antimicrobial-resistant bacteria in Cambodia with portable laboratory equipment

This study uses portable lab equipment to analyze antimicrobial-resistant bacteria in Cambodia, identifying specific resistance genes and their plasmid locations.

Influenza virus ribonucleoprotein complex formation occurs in the nucleolus

This study identifies the nucleolus as the site of vRNP formation and vRNA replication in influenza virus-infected cells.

Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells

This study uses ACE2-expressing human iPS cells to model SARS-CoV-2 infection and shows sex-based differences in viral production.

Emergence and evolution of antimicrobial resistance genes and mutations in Neisseria gonorrhoeae

This study traces the emergence and spread of antimicrobial resistance in Neisseria gonorrhoeae by analyzing genome sequences from multiple countries and time periods, revealing recombination events and antibiotic-driven mutations.

Comparison of de-duplication methods used by WHO Global Antimicrobial Resistance Surveillance System (GLASS) and Japan Nosocomial Infections Surveillance (JANIS) in the surveillance of antimicrobial resistance

This study compares de-duplication methods from WHO GLASS and JANIS systems for AMR surveillance, finding small differences in patient counts and resistance percentages for E. coli.

Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam

The paper characterizes blaNDM-1-carrying plasmids in Vietnamese Enterobacterales isolates, identifying horizontal plasmid transfer and resistance gene co-occurrence.

Long-read shotgun metagenome sequencing using PromethION uncovers novel bacteriophages, their abundance, and interaction with host bacterial immunity in the oral microbiota

This study uses long-read metagenomic sequencing to identify novel bacteriophages and their interactions with host immunity in the oral microbiota.