Author

K. D. Hagen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

S. C. Dawson· 5 shared C. Nosala· 4 shared A. Aebischer· 2 shared A. Mueller· 2 shared C. Klotz· 2 shared M. Laue· 2 shared A. Motyckova· 1 shared D. Holthaus· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

5 shared papersMicrobiology

S. C. Dawson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Dynamic ventral disc contraction is necessary for Giardia attachment and host pathology

C. Nosala, K. D. Hagen, S. L. Guest, N. A. Hilton, A. Mueller, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows Giardia's ventral disc contracts during attachment, causing host cell damage, and identifies three contraction types that reduce disc size.

bioRxiv · Jul 4, 2023 · PreprintMicrobiology

The domed architecture of Giardias ventral disc is necessary for attachment and host pathogenesis

K. D. Hagen, C. Nosala, N. Hilton, A. Mueller, D. Holthaus, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows that Giardia's ventral disc, shaped by MBP, is essential for attachment and causing host epithelial barrier damage.

bioRxiv · Jul 2, 2023 · PreprintMicrobiology

Cas9-mediated gene disruption in tetraploid Giardia intestinalis

V. Horackova, L. Voleman, K. D. Hagen, M. Petru, M. Vinopalova, F. Weisz, N. Janowicz, L. Markova, A. Motyckova, P. Tumova, S. C. Dawson, P. Dolezal

This study demonstrates the successful use of CRISPR/Cas9 to disrupt multiple genes in Giardia intestinalis, achieving full knock-out of three genes and partial disruption of an essential gene.

bioRxiv · Apr 21, 2021 · PreprintCell Biology

Robust and stable transcriptional repression in Giardia using CRISPRi

S. G. McInally, K. D. Hagen, C. Nosala, J. Williams, K. Nguyen, J. Booker, K. Jones, S. C. Dawson

This study develops CRISPRi for stable transcriptional repression in Giardia, demonstrating efficient gene knockdown and phenotypic effects.

bioRxiv · Sep 28, 2018Microbiology

Transcriptomic profiling of high-density Giardia foci encysting in the murine proximal intestine

J. K. Pham, C. Nosala, E. Y. Scott, K. F. Nguyen, K. D. Hagen, H. N. Starcevich, S. C. Dawson

This study compares in vivo gene expression of Giardia in high-density gut foci with axenic culture, finding higher expression of encystation-related genes and identifying novel cyst-specific proteins.

Frontiers in Cellular and Infection Microbiology · May 31, 2017Peer-reviewedMicrobiology