Author

C. Klotz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Aebischer· 2 shared A. Mueller· 2 shared C. Nosala· 2 shared D. Holthaus· 2 shared K. D. Hagen· 2 shared M. Laue· 2 shared S. C. Dawson· 2 shared S. Krug· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

A. Aebischer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dynamic ventral disc contraction is necessary for Giardia attachment and host pathology

C. Nosala, K. D. Hagen, S. L. Guest, N. A. Hilton, A. Mueller, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows Giardia's ventral disc contracts during attachment, causing host cell damage, and identifies three contraction types that reduce disc size.

bioRxiv · Jul 4, 2023 · PreprintMicrobiology

The domed architecture of Giardias ventral disc is necessary for attachment and host pathogenesis

K. D. Hagen, C. Nosala, N. Hilton, A. Mueller, D. Holthaus, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows that Giardia's ventral disc, shaped by MBP, is essential for attachment and causing host epithelial barrier damage.

bioRxiv · Jul 2, 2023 · PreprintMicrobiology

Oncogenic signalling is coupled to colorectal cancer cell differentiation state

T. Sell, C. Klotz, M. M. Fischer, R. Astaburuaga-Garciia, S. Krug, J. Drost, H. Clevers, M. Morkel, N. Bluthgen

This study shows oncogenic signalling in colorectal cancer is linked to cell differentiation states through a defined axis, with mutations affecting stemness and differentiation.

bioRxiv · Apr 7, 2022 · PreprintCancer Biology

Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis

M. Kraft, D. Holthaus, S. Krug, G. Holland, J.-D. Schulzke, T. Aebischer, C. Klotz

This study uses human organoids to investigate how Giardia duodenalis infection disrupts intestinal epithelial barriers, identifying early ion transport changes followed by tight junction breakdown.

bioRxiv · Nov 17, 2020 · PreprintMicrobiology