Author

S. C. Dawson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Organism:rat· 2

Frequent Co-Authors

C. Nosala· 5 shared K. D. Hagen· 5 shared S. G. McInally· 3 shared A. Aebischer· 2 shared A. Mueller· 2 shared C. Klotz· 2 shared J. K. Pham· 2 shared M. Laue· 2 shared

Activity by Year

2016-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

C. Nosala

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Dynamic ventral disc contraction is necessary for Giardia attachment and host pathology

C. Nosala, K. D. Hagen, S. L. Guest, N. A. Hilton, A. Mueller, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows Giardia's ventral disc contracts during attachment, causing host cell damage, and identifies three contraction types that reduce disc size.

bioRxiv · Jul 4, 2023 · PreprintMicrobiology

The domed architecture of Giardias ventral disc is necessary for attachment and host pathogenesis

K. D. Hagen, C. Nosala, N. Hilton, A. Mueller, D. Holthaus, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows that Giardia's ventral disc, shaped by MBP, is essential for attachment and causing host epithelial barrier damage.

bioRxiv · Jul 2, 2023 · PreprintMicrobiology

Cas9-mediated gene disruption in tetraploid Giardia intestinalis

V. Horackova, L. Voleman, K. D. Hagen, M. Petru, M. Vinopalova, F. Weisz, N. Janowicz, L. Markova, A. Motyckova, P. Tumova, S. C. Dawson, P. Dolezal

This study demonstrates the successful use of CRISPR/Cas9 to disrupt multiple genes in Giardia intestinalis, achieving full knock-out of three genes and partial disruption of an essential gene.

bioRxiv · Apr 21, 2021 · PreprintCell Biology

Length-dependent disassembly maintains four different flagellar lengths in Giardia

S. G. McInally, J. Kondev, S. C. Dawson

The paper investigates how Giardia lamblia maintains four different flagellar lengths through length-dependent disassembly mediated by kinesin-13, balancing length-independent IFT assembly.

bioRxiv · May 22, 2019Cell Biology

Robust and stable transcriptional repression in Giardia using CRISPRi

S. G. McInally, K. D. Hagen, C. Nosala, J. Williams, K. Nguyen, J. Booker, K. Jones, S. C. Dawson

This study develops CRISPRi for stable transcriptional repression in Giardia, demonstrating efficient gene knockdown and phenotypic effects.

bioRxiv · Sep 28, 2018Microbiology

Giardia colonizes and encysts in high density foci in the murine small intestine

N. Barash, C. Nosala, J. K. Pham, S. G. McInally, S. Gourguechon, B. McCarthy-Sinclair, S. C. Dawson

This paper uses bioluminescent imaging to study Giardia infection dynamics in mice, revealing non-uniform colonization and encystation patterns in high-density gut foci.

mSphere · Jun 28, 2017Peer-reviewedMicrobiology

Transcriptomic profiling of high-density Giardia foci encysting in the murine proximal intestine

J. K. Pham, C. Nosala, E. Y. Scott, K. F. Nguyen, K. D. Hagen, H. N. Starcevich, S. C. Dawson

This study compares in vivo gene expression of Giardia in high-density gut foci with axenic culture, finding higher expression of encystation-related genes and identifying novel cyst-specific proteins.

Frontiers in Cellular and Infection Microbiology · May 31, 2017Peer-reviewedMicrobiology

Giardia alters commensal microbial diversity throughout the murine gut

N. R. Barash, J. G. Maloney, S. Singer, S. C. Dawson

This study investigates how Giardia infection affects microbial diversity in the murine gut, finding systemic dysbiosis with increased Proteobacteria and reduced Firmicutes and Melainabacteria.

bioRxiv · Nov 11, 2016Microbiology