Author

D. Holthaus

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Quevedo-Olmos· 2 shared C. Klotz· 2 shared M. Ehsani· 2 shared M. Mangler· 2 shared N. Hedemann· 2 shared T. F. Meyer· 2 shared A. Aebischer· 1 shared A. Mueller· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

A. Quevedo-Olmos

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of ADAM17 increases cytotoxic effect of cisplatin in cervical spheroids and organoids

D. Holthaus, C. Rogmans, I. Gursinski, A. Quevedo-Olmos, M. Ehsani, M. Mangler, I. Floerkemeier, J. P. Weimer, T. F. Meyer, N. Maass, D. O. Bauerschlag, N. Hedemann

This study shows that inhibiting ADAM17 enhances cisplatin's cytotoxic effect in cervical cancer spheroids and organoids, suggesting ADAM17 as a potential target for overcoming chemoresistance.

bioRxiv · Jan 27, 2024Cancer Biology

γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids

J. Dong, D. Holthaus, C. Peters, S. Koster, M. Ehsani, A. Quevedo-Olmos, H. Berger, M. Zarobkiewicz, M. Mangler, R. Kumar Gurumurthy, N. Hedemann, C. Chumduri, D. Kabelitz, T. F. Meyer

This study evaluates γδ T cell-mediated cytotoxicity against cervical organoids, finding that HPV-transformed and cancerous organoids are more susceptible than healthy ones.

bioRxiv · Jul 25, 2023Immunology

The domed architecture of Giardias ventral disc is necessary for attachment and host pathogenesis

K. D. Hagen, C. Nosala, N. Hilton, A. Mueller, D. Holthaus, M. Laue, C. Klotz, A. Aebischer, S. C. Dawson

This study shows that Giardia's ventral disc, shaped by MBP, is essential for attachment and causing host epithelial barrier damage.

bioRxiv · Jul 2, 2023 · PreprintMicrobiology

Dissection of barrier dysfunction in organoid-derived human intestinal epithelia induced by Giardia duodenalis

M. Kraft, D. Holthaus, S. Krug, G. Holland, J.-D. Schulzke, T. Aebischer, C. Klotz

This study uses human organoids to investigate how Giardia duodenalis infection disrupts intestinal epithelial barriers, identifying early ion transport changes followed by tight junction breakdown.

bioRxiv · Nov 17, 2020 · PreprintMicrobiology

Direct antiviral activity of interferon stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells

D. Holthaus, A. Vasou, C. G. Bamford, J. Andrejeva, C. Paulus, R. E. Randall, J. McLauchlan, D. J. Hughes

The paper shows that ISG15-deficient cells are resistant to paramyxovirus infection due to direct antiviral activity of ISGs, but prolonged IFN treatment causes resistance through translational inhibition.

bioRxiv · Dec 12, 2019Immunology