S. Prekovic

Tumor-derived colorectal cancer organoids induce a unique Treg cell population through direct modulation of CD4+ T cell differentiation.

This study shows CRC tumor organoids induce Treg cells via TGFβ-dependent differentiation, with distinct transcriptional profiles and prognostic relevance in CRC patients.

Glycolytic reprogramming shapes the epigenetic landscape of activated CD4+ T Cells in Juvenile Idiopathic Arthritis

This study shows that glycolytic reprogramming in JIA CD4+ T cells drives epigenetic changes linked to inflammation, with potential therapeutic implications.

A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator

This study uses a CRISPR screen to identify genes critical for macrophage-mediated killing of prostate cancer cells, revealing AR as an immunomodulator that promotes resistance to macrophage attack.

Crosstalk between the glucocorticoid and mineralocorticoid receptor boosts glucocorticoid-induced killing of multiple myeloma cells

This study shows that combining dexamethasone with spironolactone enhances myeloma cell killing through GR-MR crosstalk, with potential for dose reduction.

Single-cell ATAC and RNA sequencing reveal pre-existing and persistent subpopulations of cells associated with relapse of prostate cancer

The paper uses single-cell ATAC and RNA sequencing to identify pre-existing and treatment-persistent stem-like cell subpopulations in prostate cancer models that predict treatment response.

Glucocorticoids regulate cancer cell dormancy

This study identifies the mechanism by which glucocorticoid receptor activation induces cancer cell dormancy through CDKN1C and FOXO1/IRS2 signaling, with implications for cancer therapy.