Author

L. Delhaye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. Eyckerman· 6 shared A. Eggermont· 2 shared B. De Paepe· 2 shared D. De Sutter· 2 shared E. Sanders· 2 shared F. Speleman· 2 shared F. Van Nieuwerburgh· 2 shared G. D. Moschonas· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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6 shared papersCancer Biology

S. Eyckerman

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics

L. Delhaye, G. D. Moschonas, D. Fijalkowska, A. Verhee, D. De Sutter, T. Van de Steene, M. De Meyer, L. Van Moortel, K. De Bosscher, S. Eyckerman

The paper introduces a T2A split-link system for proximity labeling proteomics to improve control over enzymatic activity and expression levels, enhancing accuracy in identifying protein interactions.

bioRxiv · Nov 3, 2023Biochemistry

MX2 restricts HIV-1 and herpes simplex virus type 1 by forming cytoplasmic biomolecular condensates that mimic nuclear pore complexes

G. D. Moschonas, L. Delhaye, R. Cooreman, F. Husers, A. Bath, D. De Sutter, E. Parthoens, A.-S. Desmet, A. Maciejczuk, H. Grzesik, S. Lippens, Z. Debyser, B. Sodeik, S. Eyckerman, X. Saelens

This study shows MX2 forms cytoplasmic condensates that mimic nuclear pore complexes to restrict HIV-1 and HSV-1 by trapping viral capsids and preventing nuclear entry.

bioRxiv · Jun 22, 2023 · PreprintMicrobiology

The fork restart factor PHF6 interacts with RRM2 and binds to H3K56ac marked nascent DNA

L. Depestel, S.-L. Bekaert, E. Sanders, C. Van Damme, A. Eggermont, S. Loontiens, L. Tilleman, F. Van Nieuwerburgh, L. Delhaye, P. Van Vlierberghe, S. Eyckerman, F. Speleman, K. Durinck

This study identifies PHF6's interaction with RRM2 and its binding to H3K56ac marked nascent DNA, revealing a role in replication fork restart and DNA damage repair.

bioRxiv · Mar 8, 2023 · PreprintCancer Biology

mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells

S. Dewaele, L. Delhaye, B. De Paepe, B. Bogaert, R. Martinez, J. Anckaert, N. Yigit, J. Nuytens, R. Van Coster, S. Eyckerman, K. Raemdonck, P. Mestdagh

This study shows that mTOR inhibition improves the delivery and effectiveness of antisense oligonucleotides in uveal melanoma cells and other cell types.

bioRxiv · Sep 29, 2021Cancer Biology

The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival

S. Dewaele, L. Delhaye, B. De Paepe, E. De Bony, J. De Wilde, K. Vanderheyden, J. Anckaert, N. Yigit, E. VandenEynde, F. Nemati, D. Decaudin, A. Jochemsen, E. Leucci, J. Vandesompele, J. Van Dorpe, , P. Mestdagh

This study shows that inhibiting the lncRNA SAMMSON reduces uveal melanoma cell growth and viability by impairing mitochondrial function and protein translation.

bioRxiv · Jan 18, 2021Cancer Biology

RRM2 is a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma

C. Nunes, L. Depestel, L. M. Mus, K. M. Keller, L. Delhaye, A. Louwagie, M. Rishfi, E. M. Dolman, V. Olexiouk, C. Bartenhagen, F. Devloed, E. Sanders, A. Eggermont, J. Van Laere, E. De Smet, , F. Speleman

This study identifies RRM2 as a therapeutic target in high-risk neuroblastoma, showing that combined RRM2 and CHK1 inhibition synergistically reduces tumor growth.

bioRxiv · Nov 25, 2020 · PreprintCancer Biology