The Metabolites NADP+ and NADPH are the Targets of the Circadian Protein Nocturnin (Curled)
M. A. Estrella, J. Du, L. Chen, S. Rath, E. Prangley, A. Chitrakar, T. Aoki, P. Schedl, J. Rabinowitz, A. Korennykh
This study identifies NADP+ and NADPH as substrates of the circadian protein Nocturnin, showing its enzymatic activity in converting these metabolites and revealing structural insights into its mechanism.
bioRxiv · Jan 30, 2019Biophysics