Author

K. Downes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell-cell communication· 1 Organism:human· 1 Assay:proteomics· 1 Organism:rat· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

A. Chalkias· 1 shared A. Gilchrist· 1 shared A. Mathur· 1 shared A. Zuppa· 1 shared C. Kempster· 1 shared E. d'Aloja· 1 shared E. Laurenti· 1 shared E. Locci· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Chalkias

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

F. A. Choudry, F. Otzen Bagger, I. C. Macaulay, S. Farrow, F. Burden, C. Kempster, H. McKinney, L. R. Olsen, N. Huang, K. Downes, T. Voet, R. Uppal, J. Martin, A. Mathur, W. h. Ouwehand, , M. Frontini

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.

bioRxiv · Feb 20, 2020 · PreprintCell Biology

Urinary biomarker and histopathological evaluation of vancomycin and piperacillin-tazobactam nephrotoxicity in comparison with vancomycin in a rat model and a confirmatory cellular model

G. M. Pais, J. Liu, S. N. Avedissian, T. Xanthos, A. Chalkias, E. d'Aloja, E. Locci, A. Gilchrist, W. C. Prozialeck, N. Rhodes, T. P. Lodise, J. C. Fitzgerald, K. Downes, A. Zuppa, M. H. Scheetz

This study evaluates kidney injury from vancomycin and piperacillin-tazobactam in rats and cells, finding no increased toxicity from the combination compared to vancomycin alone.

bioRxiv · Mar 6, 2019Pharmacology & Toxicology