Author

L. R. Olsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

M. B. Barnkob· 2 shared A. Mathur· 1 shared A. Townsend· 1 shared A. V. Hadjinicolaou· 1 shared C. J. Wu· 1 shared C. Kempster· 1 shared C. Kulicke· 1 shared C. Mangum· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

M. B. Barnkob

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Author profile →

4 papers

Recent·Most cited

Coordinated Immune Cell Networks in the Bone Marrow Microenvironment Define the Graft versus Leukemia Response with Adoptive Cellular Therapy

K. Maurer, C. Park, S. Mani, M. Borji, L. Penter, Y. Jin, J. Y. Zhang, C. Shin, J. R. Brenner, J. Southard, S. Krishna, W. Lu, H. Lyu, D. Abbondanza, C. Mangum, , E. Azizi

The paper analyzes single-cell data from bone marrow samples to identify immune cell interactions that predict response to adoptive cellular therapy in myeloid leukemia.

bioRxiv · Feb 9, 2024 · PreprintCancer Biology

Target isoforms are an overlooked challenge and opportunity in chimeric antigen receptor cell therapy

M. B. Barnkob, K. Vitting-Seerup, L. R. Olsen

The paper examines protein isoform switching in solid cancers as a challenge and opportunity for CAR therapy, highlighting its impact on tumor relapse.

bioRxiv · Mar 2, 2022Cancer Biology

Single cell transcriptional characterization of human megakaryocyte lineage commitment and maturation

F. A. Choudry, F. Otzen Bagger, I. C. Macaulay, S. Farrow, F. Burden, C. Kempster, H. McKinney, L. R. Olsen, N. Huang, K. Downes, T. Voet, R. Uppal, J. Martin, A. Mathur, W. h. Ouwehand, , M. Frontini

This study uses single-cell RNA sequencing to analyze human bone marrow HSCs and MKs, identifying MK primed HSC clusters and transcriptional changes during MK maturation and their association with myocardial infarction.

bioRxiv · Feb 20, 2020 · PreprintCell Biology

Semaphorin 3A induces cytoskeletal paralysis in tumor-specific CD8+ T cells

M. B. Barnkob, Y. S. Michaels, V. Andre, P. S. Macklin, U. Gileadi, S. Valvo, M. Rei, C. Kulicke, J.-L. Chen, V. Jain, V. Woodcock, H. Colin-York, A. V. Hadjinicolaou, Y. Kong, V. Mayya, , V. Cerundolo

This study shows Sema3A inhibits tumor-specific CD8+ T cell function by inducing cytoskeletal paralysis via NRP1 in the tumor microenvironment.

bioRxiv · Nov 20, 2019Immunology