K. E. DelGiorno

This study identifies BMP signaling as a driver of ID1 and ID3 upregulation in pancreatitis and PDAC, linking it to poor patient survival and disease progression.

This study shows CD73-generated adenosine reduces neutrophil-driven tissue damage and metaplasia in pancreatitis by promoting inflammation resolution.

The paper investigates phosphohistidine (pHis) pathway regulation in the mouse pancreatic tumor microenvironment using novel antibodies and identifies deregulated pHis signals and potential substrates.

The paper identifies key eicosanoid changes in pancreatic tumorigenesis and the cell types responsible for their synthesis using mouse models and patient samples.

The paper uses single-cell RNA sequencing to identify a conserved metaplasia program in pancreatic injury, revealing mucin/ductal populations and neoplastic transformation potential.

This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.