I. Matsumoto

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

Alveolar regeneration following viral infection is independent of tuft cells

This study shows that alveolar regeneration after viral infection occurs independently of tuft cells, with ectopic basal progenitor cells generating alveolar epithelial cells through distinct differentiation paths.

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair

The paper identifies heterogeneous tuft cells in injured lungs that develop independently of Type 2 cytokines and are not essential for dysplastic repair.

Tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically initiate lung type 2 inflammation

The paper shows that tuft cell-produced cysteinyl leukotrienes and IL-25 synergistically drive lung type 2 inflammation in response to aeroallergens.

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury

The paper uses single-cell RNA sequencing to identify a conserved metaplasia program in pancreatic injury, revealing mucin/ductal populations and neoplastic transformation potential.

Tuft cells restrain pancreatic tumorigenesis through paracrine eicosanoid signaling

This study shows that tuft cells suppress pancreatic tumorigenesis by producing anti-inflammatory prostaglandin D2, which inhibits stromal activation, and identifies their protective role in early disease progression.

SMAD3 Determines Conventional versus Plasmacytoid Dendritic Cell Fates

This study identifies SMAD3 as a key regulator determining conventional DC versus plasmacytoid DC differentiation through distinct gene regulatory mechanisms.