Author

M. A. Badgley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. F. Palermo· 4 shared S. A. Sastra· 4 shared K. P. Olive· 3 shared A. Andren· 2 shared A. Iuga· 2 shared C. A. Lyssiotis· 2 shared G. A. Manji· 2 shared H. C. Maurer· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersCancer Biology

C. F. Palermo

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5 papers

Recent·Most cited

Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma

U. N. Wasko, J. Jiang, A. C. Garcia, Y. Wang, B. Lee, M. Orlen, K. Drizyte-Miller, M. Menard, J. Dilly, S. A. Sastra, C. F. Palermo, T. Dalton, M. C. Hasselluhn, A. R. Decker-Farrell, S. Chang, , R. H Vonderheide

This study evaluates the therapeutic potential of RMC-7977, a broad-spectrum RAS inhibitor, in pancreatic ductal adenocarcinoma models, showing strong anti-tumor effects with minimal impact on normal tissues.

bioRxiv · Dec 3, 2023 · PreprintCancer Biology

Ras-dependent activation of BMAL2 regulates hypoxic metabolism in pancreatic cancer

A. Curiel-Garcia, S. Holmstrom, C. Castillo, C. F. Palermo, S. A. Sastra, A. Andren, L. Tomassoni, Z. Li, T. LeLarge, I. Sagalovskiy, D. R. Ross, W. Wong, K. Shaw, J. Genkinger, H. Hibshoosh, , K. P. Olive

This study identifies BMAL2 as a KRAS-dependent regulator of hypoxic metabolism in pancreatic cancer, showing it stabilizes HIF1A and destabilizes HIF2A under hypoxia.

bioRxiv · Mar 19, 2023 · PreprintCancer Biology

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

J. Garcia-Bermudez, S. Prasad, L. Baudrier, M. A. Badgley, Y. Liu, K. La, M. Soula, R. T. Williams, N. Yamaguchi, R. F. Hwang, L. J. Taylor, E. De Stanchina, B. Rostandy, H. Alwaseem, H. Molina, , K. Birsoy

The paper identifies GOT2-catalyzed mitochondrial aspartate synthesis as essential for pancreatic tumor cell proliferation under hypoxia, but this dependency is bypassed by hypoxia-induced macropinocytosis.

bioRxiv · Feb 2, 2021Cancer Biology

GOT1 Inhibition Primes Pancreatic Cancer for Ferroptosis through the Autophagic Release of Labile Iron

D. M. Kremer, B. S. Nelson, L. Lin, E. Yarosz, C. J. Halbrook, S. A. Kerk, P. Sajjakulnukit, A. Myers, G. Thurston, S. Hou, E. S. Carpenter, A. Andren, Z. Nwosu, N. Cusmano, S. Wisner, , C. A. Lyssiotis

This study shows that inhibiting GOT1 in pancreatic cancer primes cells for ferroptosis by promoting autophagy-mediated release of labile iron.

bioRxiv · Feb 28, 2020 · PreprintCancer Biology

Induction of pancreatic tumor-selective ferroptosis through modulation of cystine import

M. A. Badgley, D. Kremer, H. C. Maurer, K. E. DelGiorno, H.-J. Lee, V. Purohit, I. Sagalovskiy, A. Ma, J. Kapillian, C. E. M. Firl, A. R. Decker, S. A. Sastra, C. F. Palermo, L. R. Andrade, P. Sajjakulnukit, , K. P. Olive

The paper shows that targeting cystine import induces ferroptosis in pancreatic tumors, leading to tumor regression and improved survival in a mouse model.

bioRxiv · Nov 1, 2019 · PreprintCancer Biology