K. Eaton

Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility

This study shows that Akkermansia muciniphila increases susceptibility to a gut pathogen under fiber-deprived conditions but reduces pathogen load on a fiber-sufficient diet.

A Pandemic-Scale Ancestral Recombination Graph for SARS-CoV-2

The paper infers an Ancestral Recombination Graph for 2.48 million SARS-CoV-2 genomes to account for recombination, providing a more accurate representation of viral genealogy than traditional trees.

Opposing diet, microbiome and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host

The paper shows that low dietary fiber promotes colitis in genetically susceptible mice by eroding mucus, while a fiber-free diet increases anti-inflammatory metabolites, highlighting microbial function over taxa in IBD regulation.

Spatial metabolomics reveals localized impact of influenza virus infection on the lung tissue metabolome

This study uses spatial metabolomics to analyze metabolic changes in lung tissue and plasma of influenza-infected mice, identifying site-specific metabolite alterations and their potential as therapeutic targets.

Mcc1229, an Stx2a-amplifying microcin, is produced in vivo and requires CirA for activity

The paper identifies Mcc1229, a microcin produced by E. coli that activates Stx2a production in EHEC, and shows it requires CirA for activity.

A rare opportunist, Morganella morganii, decreases severity of polymicrobial catheter-associated urinary tract infection

This study shows that Morganella morganii reduces urease activity in Proteus mirabilis and prevents urease enhancement by other bacteria, thereby decreasing severity of polymicrobial catheter-associated urinary tract infections.