M. S. Desai

Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility

This study shows that Akkermansia muciniphila increases susceptibility to a gut pathogen under fiber-deprived conditions but reduces pathogen load on a fiber-sufficient diet.

Gut microbiome-based prediction of autoimmune neuroinflammation

The paper identifies a microbial risk factor for autoimmune neuroinflammation by analyzing microbiota compositions and host immune responses in a mouse model of multiple sclerosis.

Maternal diet and gut microbiome composition modulate early life immune development

This study shows that maternal diet and gut microbiome composition affect early immune development in offspring by altering microbial colonization and immune gene expression.

Opposing diet, microbiome and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host

The paper shows that low dietary fiber promotes colitis in genetically susceptible mice by eroding mucus, while a fiber-free diet increases anti-inflammatory metabolites, highlighting microbial function over taxa in IBD regulation.

Mucin-degrading gut bacteria promote anti-parasitic immunity

This study shows that mucin-degrading gut bacteria influence anti-parasitic immunity by modulating host immune responses, with dietary fiber affecting this interaction.

Deprivation of dietary fiber in specific-pathogen-free mice promotes susceptibility to the intestinal mucosal pathogen Citrobacter rodentium

This study shows that a low-fiber diet in SPF mice increases susceptibility to Citrobacter rodentium by altering gut microbiota and reducing mucosal barrier integrity.

Dietary modulation alters susceptibility to Listeria monocytogenes and Salmonella typhimurium in a gut microbiota-independent manner

This study shows that a low-fiber diet reduces susceptibility to Listeria monocytogenes and Salmonella typhimurium in a microbiota-independent manner in gnotobiotic mice.