A. Sundararajan

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution

The paper characterizes a large collection of Bacteroidales isolates from the human gut, revealing genomic and metabolomic diversity and horizontal gene transfer across species.

Predictive simulation of human movement in OpenSim using floating-base task space control

This paper introduces a floating-base task space control framework for predictive human movement simulations in OpenSim, enabling realistic gait generation through task prioritization and dynamic contact handling.

Structure-Activity Relationship Studies of Novel Gut-derived Lantibiotics Against Human Gut Commensals

The paper characterizes six gut-derived nisin-like lantibiotics, evaluates their antimicrobial activity against pathogens and commensals, and identifies key residues affecting their activity.

A ubiquitous mobile genetic element disarms a bacterial antagonist of the gut microbiota

The paper shows that a mobile genetic element inverts the antagonistic behavior of Bacteroides fragilis by disabling its native system and enhancing fitness through a new weapon.

Virulence and genomic diversity among clinical isolates of ST1 (BI/NAP1/027) Clostridioides difficile

This study identifies a 69 base-pair deletion in the cdtR gene that attenuates virulence in ST1 C. difficile strains without affecting colonization.

Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration

The paper identifies gut bacteria that use dietary and host-derived metabolites as electron acceptors in anaerobic respiration, revealing new metabolic pathways and reductase evolution.

Mfd affects global transcription and the physiology of stressed Bacillus subtilis cells

This study shows that Mfd affects global transcription and bacterial physiology under stress, with 1,997 genes differentially expressed in mfd mutants.