Author

M. Mak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:imaging· 3 Research Focus:cell type annotation· 2 Approach:microscopy & imaging analysis· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

X. Gong· 3 shared Z. Chen· 2 shared A. Bauer· 1 shared A. Cabral· 1 shared A. Malandrino· 1 shared A. Rossello· 1 shared B. E. Ehrlich· 1 shared B. Fabry· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersCancer Biology

X. Gong

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Adaptation to volumetric compression drives hepatoblastoma cells to an apoptosis-resistant and invasive phenotype

X. Gong, N. Ogino, M. F. Leite, Z. Chen, R. Liu, E. Kruglov, K. Flores, A. Cabral, G. M. M. Mendes, B. E. Ehrlich, M. Mak

This study shows that volumetric compression in liver cancer cells leads to transcriptional reprogramming, increased invasiveness, and chemoresistance, with potential reversal via calcium signaling.

bioRxiv · Oct 8, 2023 · PreprintCancer Biology

Volumetric Compression Shifts Rho GTPase Balance and Induces Mechanobiological Cell State Transition

X. Gong, R. Nguyen, Z. Chen, X. Zhang, M. Mak

The paper investigates how volumetric compression affects Rho GTPase balance and mechanobiological cell state transitions through physical and molecular changes.

bioRxiv · Oct 8, 2023 · PreprintBiophysics

Instant Assembly of Collagen for Scaffolding, Tissue Engineering, and Bioprinting

X. Gong, Z. Wen, Z. Liang, H. Xiao, S. Lee, T. Wright, R. Y. Nguyen, A. Rossello, M. Mak

This paper introduces TRACE, a method for instant collagen gelation and patterning, enabling applications in biofabrication and tissue engineering.

bioRxiv · Oct 8, 2023 · PreprintBioengineering

Fiber alignment in 3D collagen networks as a biophysical marker for cell contractility

D. Boehringer, A. Bauer, I. Moravec, L. Bischof, D. Kah, C. Mark, T. J. Grundy, E. Goerlach, G. M. O'Neill, S. Budday, P. Strissel, R. Strick, A. Malandrino, R. Gerum, M. Mak, , B. Fabry

This study uses fiber alignment and density in 3D collagen networks as a proxy for cell traction forces, validated in hepatic stellate cells and glioblastoma cell lines, and provides an open-source tool for drug screening.

bioRxiv · Jun 28, 2023Biophysics

Cytoskeletal tension actively sustains the migratory T cell synaptic contact

S. Kumari, M. Mak, Y. Poh, M. Tohme, N. Watson, M. Melo, E. Janssen, M. Dustin, R. Geha, D. Irvine

This study identifies a mechanical mechanism involving cytoskeletal tension that sustains T cell-APC synaptic contact symmetry and stability.

bioRxiv · May 4, 2019Cell Biology